The way audio cables are constructed can certainly make a difference to their sonic characteristics. Over the past several years I have been comparing the sound transmission characteristics of different copper conductors. In addition to the conductors, different geometries, dielectric material, and shielding can make a cable sound different. While these can influence the sound, I feel the primary sonic impressions I have been hearing have to do with the interaction of conductors carrying an audio signal. Stay tuned for a full write-up on stranded copper vs solid core copper audio wire.